Clinical Toxicology Newsletter

Stay current without doing the hunting.

ToxSignal is the clinical toxicology newsletter from Dr. William Bundy Jr., PharmD — covering emerging drug threats, regulatory changes in drug testing, lab technology updates, and practice-relevant science. Delivered free, written for professionals.

2 Issues Published
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Emerging drug threats

Novel substances, adulterants, and new combinations hitting the street — covered before most clinical education catches up.

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Regulatory & policy updates

Changes to drug testing regulations, laboratory standards, federal guidance, and what they mean for your practice or program.

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Science that moves practice

New research on detection windows, immunoassay gaps, confirmatory testing, and result interpretation — translated into clinical language.

What to Expect

Each issue covers what matters now

Drug Trends
What's in the supply
Novel substances · Adulterants · Polydrug combinations
Emerging Threats Real-Time Intelligence
Coverage New synthetic opioids, novel adulterants, and substances entering the street supply before standard panels detect them
Why It Matters Most clinical teams learn about new threats months after they've already arrived
Regulatory
Policy & rule changes
Federal guidance · Lab standards · Program compliance
Regulatory Updates Compliance Impact
Coverage Changes to SAMHSA guidelines, drug court testing requirements, federal agency rules, and laboratory standards
Why It Matters Regulatory changes affect how results are collected, interpreted, and acted on — often quietly
Science
Research that moves practice
Detection windows · Immunoassay science · Interpretation frameworks
Clinical Science Practical Application
Coverage New research on drug testing science — translated from the literature into language that's actually usable in a clinical or legal setting
Why It Matters The gap between published research and clinical practice is where decisions go wrong
Issue Archive

Past issues

Subscribe for new issues →
Issue #01 May 2026
Medetomidine
Drug Trend Spotlight · Regulatory · Science
Adulterant Alert DOT Rule Change JAMA MOUD Consensus
Spotlight Medetomidine now detected in 37% of fentanyl samples — distinct withdrawal, not reversed by naloxone
Regulatory DOT oral fluid workaround effective June 10 · SAMHSA funding cuts vs. drug control strategy
Science 42-expert hospital MOUD consensus (JAMA) · ED buprenorphine RCT, 29 sites
Read Issue #01
New
Issue #02 May 2026
Medetomidine
Drug Trend Spotlight · Regulatory · Science
Adulterant Alert Cannabis Rescheduling MOUD Duration Evidence
Spotlight Medetomidine surges to 8,233 NFLIS reports in 2025 — no human reversal agent, severe withdrawal
Regulatory Cannabis rescheduling fractures in Congress · DOT oral fluid rule effective June 10
Science 4-year MOUD survival benefit (Hayes et al.) · Hospital MOUD initiation consensus (JAMA)
Read Issue #02
Issue #03 Coming soon
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About ToxSignal

Why ToxSignal exists

Clinical toxicology moves fast — and the clinicians, drug court professionals, and legal practitioners who rely on drug testing science rarely have time to track it. Regulatory guidance changes. New substances appear in the supply. Published research takes years to reach clinical practice.

ToxSignal closes that gap. Each issue pulls together what's relevant right now — drug trends making news, regulatory changes that affect practice, and science worth knowing — and delivers it in plain clinical language, without requiring a journal subscription or a literature search.

Written by Dr. William Bundy Jr., PharmD, clinical toxicologist and drug testing specialist, and distributed free to subscribers who want to stay current without doing the hunting themselves.

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Written for clinicians and program staff

Not a journal. Not a press release. Written for the people who actually use drug testing results in clinical, legal, and program settings.

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Curated, not comprehensive

Each issue covers what's most relevant — not everything that happened. The goal is to be useful in the time it takes to read, not exhaustive.

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Linked to deeper resources

When a topic warrants more depth, issues link to Tox In Focus reference guides for the full clinical picture.

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Delivered directly, free

No paywall. No algorithm. Straight to your inbox when a new issue is ready.

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